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KMID : 0923620160160050311
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Immune Network
2016 Volume.16 No. 5 p.311 ~ p.315
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Genetic Characteristics and Immunogenicity of Pandemic H1N1 Influenza Virus Isolate from Pig in Korea
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Moon Hyoung-Joon
Oh Jin-Sik
Na Woon-Sung
Yeom Min-Joo
Han Sang-Yoon
Kim Sung-Jae
Park Bong-Kyun
Song Dae-Sub
Kang Bo-Kyu
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Abstract
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A pandemic influenza A (H1N1) virus strain was isolated from a pig farm in Korea in December 2009. The strain was propagated in and isolated from both the Madin-Darby canine kidney cell line and embryonated eggs. The partial and complete sequences of the strain were identical to those of A/California/04/2009, with >99% sequence similarity in the HA, NA, M, NS, NP, PA, PB1, and PB2 genes. The isolated strain was inactivated and used to prepare a swine influenza vaccine. This trial vaccine, containing the new isolate that has high sequence similarity with the pandemic influenza A (H1N1) virus, resulted in seroconversion in Guinea pigs and piglets. This strain could therefore be a potential vaccine candidate for swine influenza control in commercial farms.
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KEYWORD
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Influenza, Pig, Vaccine, H1N1
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